Wednesday, June 14, 2023

What causes high cholesterol—a genetic condition or a dietary issue? According to experts

 1. Actually, it's a combination of the two:

 high cholesterol can be caused by habits or genetic problems. It is fundamental for know this in light of the fact that the course of solution for elevated cholesterol significantly relies upon its temperament.

"Some patients have high cholesterol because of their genes or because of their lifestyle; there is some hereditary anomaly which inclines them toward elevated cholesterol levels like familial hypertriglyceridemia. According to Dr. Sanjeev Chaudhary, Director of Cardiology at Marengo Asia Hospitals in Gurugram, "They have their high cholesterol level because of a genetic problem, and whatever they do, their cholesterol remains high."

"What's more, in a large portion of these patients, way of life change can't bring about typical cholesterol. Therefore, unless they take medication, patients with a genetic predisposition to high cholesterol will continue to have high cholesterol, he adds.

2. A defect on chromosome 19 causes familial hypercholesterolemia. 

High cholesterol can be caused by poor diet or genetic predisposition. Family hypercholesterolemia is caused by a genetic defect on chromosome 19. Dr. Bharat Vijay Purohit, Senior Consultant Interventional Cardiologist & Director of Cath Lab, Yashoda hospitals, Hyderabad, explains that it can be heterozygous (a defect in only one parent's gene) or homozygous (a defect in both parents' genes).

Dr. Purohit adds that cholesterol deposits on the elbow, knee, or around the eyelids (xanthelasma) or iris in the eye (corneal arcus) are seen in childhood in homozygous hypercholesterolemia.

If you have homozygous hypercholesterolemia, which means you have two sets of defective genes—one from each parent—you are more likely to develop heart disease at an early age. The body's ability to eliminate LDL, also known as low density lipoprotein cholesterol, becomes more difficult in this circumstance.

3. How do you know if it's a lifestyle disorder or a genetic predisposition?

 "Usually, people with genetic predisposition have very high cholesterol levels compared to people with lifestyle disorders. Second, there are genetic markers that can be tested to see if the patient has a genetic predisposition or a lifestyle disorder. Dr. Chaudhary elaborates, "There are specific indications to use those tests, and those tests are expensive." He advises consulting your doctor to determine whether you need to be tested for a genetic family history of high cholesterol.

4.So, what should be possible?

"The valid statement is that there are explicit treatments accessible for them, drugs can work. We will soon have genetic treatment so that they are permanently cured, but until then, they can take medicines to lower their cholesterol levels,” he says. "Gene therapy is also a very big thing that is coming up."

For other people who don't have this hereditary inclination, elevated cholesterol can likewise occur because of undesirable way of life propensities. Diabetes, bad eating habits, inactivity, smoking, and possibly a sedentary lifestyle are all potential causes. According to Dr. Chaudhury, "if they are very strict in their lifestyle modification, they can have normal cholesterol levels without medicines." Therefore, lifestyle modification will work for those patients.

5. A bad diet is a big part of high cholesterol 

Dr. Purohit says that a bad diet is also a big part of high cholesterol. Diet wealthy in immersed fats (for example pork sheep poultry with skin entire egg, unskimmed milk, Coconut oil, palm oil, and so forth.) and trans fat, which can be found in things like potato chips, buttered popcorn, cookies, donuts, and other baked goods. increment the gamble of elevated cholesterol," says Dr Purohit. " Dietary rules recommend restricting dietary cholesterol admission to less then 300 mg each day," he adds.

6.The action item message

"It is prescribed to do the primary lipid profile test around the age of 10 years and afterward in like clockwork," suggests Dr Purohit.

High cholesterol is a silent killer, especially when it poses a risk to the heart that is life-threatening, according to experts, who have urged finding the root cause of the rising cholesterol level.

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